Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageRegulation of p53 function and stability by phosphorylationTwo cellular proteins that bind to wild-type but not mutant p53CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancerp53 oligomerization and DNA looping are linked with transcriptional activationThe dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA bindingEstrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.Tracing the protectors path from the germ line to the genome.Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivationA single-molecule characterization of p53 search on DNARegulation of transactivation-independent proapoptotic activity of p53 by FOXO3aA functional p53-responsive intronic promoter is contained within the human mdm2 gene.Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures.p53 and p73 display common and distinct requirements for sequence specific binding to DNASpecific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solutionDirect interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivationCancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.Dancing on DNA: kinetic aspects of search processes on DNAEffects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.Reversal of in vitro p53 squelching by both TFIIB and TFIIDReciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulationp53 domains: structure, oligomerization, and transformation.p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting.Identification of an additional negative regulatory region for p53 sequence-specific DNA bindingA meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.Transcriptional regulation by p53.Therapeutic strategies for head and neck cancer based on p53 status.Stimulation of polyomavirus DNA replication by wild-type p53 through the DNA-binding site.The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA bindingReactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein.Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis
P2860
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P2860
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Conformational shifts propagat ...... binding to select p53 mutants.
@en
type
label
Conformational shifts propagat ...... binding to select p53 mutants.
@en
prefLabel
Conformational shifts propagat ...... binding to select p53 mutants.
@en
P2860
P1433
P1476
Conformational shifts propagat ...... binding to select p53 mutants
@en
P2093
A N Kandil
T D Halazonetis
P2860
P304
P356
10.1002/J.1460-2075.1993.TB06199.X
P407
P577
1993-12-01T00:00:00Z