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Thioridazine: resurrection as an antimicrobial agent?Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspectsIn silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channelIon channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathChanges in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channelAntiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model.Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.L-type calcium current (ICa,L) and inward rectifier potassium current (IK1) are involved in QT prolongation induced by arsenic trioxide in rat.Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.Post-transcriptional control of human ether-a-go-go-related gene potassium channel protein by alpha-adrenergic receptor stimulation.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiashERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562The Link between Inactivation and High-Affinity Block of hERG1 ChannelsA k-nearest neighbor classification of hERG K(+) channel blockers.Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis.The hERG potassium channel as a therapeutic target.New potential binding determinant for hERG channel inhibitors.Principles of safety pharmacology.Future directions for drug transporter modelling.Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stabilityThe organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channelState-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.The emerging role of antiarrhythmic compounds with atrial selectivity in the management of atrial fibrillation.Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic aciDrug-induced QT-interval prolongation: considerations for clinicians.Revealing the structural basis of action of hERG potassium channel activators and blockers.Keeping the rhythm: hERG and beyond in cardiovascular safety pharmacology.Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.Keep the QT interval: it is a reliable predictor of ventricular arrhythmias.Development of Safe Drugs: The hERG Challenge.Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.Interactions at human ether-à-go-go-related gene channels.Molecular determinants of hERG channel block by terfenadine and cisapride.Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block.Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells.Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Molecular determinants of HERG channel block.
@en
type
label
Molecular determinants of HERG channel block.
@en
prefLabel
Molecular determinants of HERG channel block.
@en
P2093
P356
P1476
Molecular determinants of HERG channel block
@en
P2093
Kaichiro Kamiya
Michael C Sanguinetti
Ryoko Niwa
P304
P356
10.1124/MOL.105.020990
P577
2006-02-10T00:00:00Z