Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.
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A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityIslet amyloid in type 2 diabetes, and the toxic oligomer hypothesisHeparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complicationsThe amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob miceTetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic miceRapid Myoglobin Aggregation through Glucosamine-Induced α-Dicarbonyl Formation.Salmon calcitonin - a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents.Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes.Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicityAmyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.Fatty acids induce amylin expression and secretion by pancreatic beta-cells.Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusionsMisfolded proteins in Alzheimer's disease and type II diabetes.Glucose- and time-dependence of islet amyloid formation in vitro.Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptideIslet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stressRecent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitusAmyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice.Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol.Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.Unique example of amyloid aggregates stabilized by main chain H-bond instead of the steric zipper: molecular dynamics study of the amyloidogenic segment of amylin wild-type and mutants.Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.Mechanism of islet amyloid polypeptide fibrillation at lipid interfaces studied by infrared reflection absorption spectroscopy.Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes.Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide.Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.
P2860
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P2860
Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Extensive islet amyloid format ...... of diabetes in a mouse model.
@en
type
label
Extensive islet amyloid format ...... of diabetes in a mouse model.
@en
prefLabel
Extensive islet amyloid format ...... of diabetes in a mouse model.
@en
P2093
P356
P1433
P1476
Extensive islet amyloid format ...... of diabetes in a mouse model.
@en
P2093
Höppener JW
Nieuwenhuis MG
Oosterwijk C
Posthuma G
Thijssen JH
P2888
P304
P356
10.1007/S001250051175
P50
P577
1999-04-01T00:00:00Z
P5875
P6179
1033188096