Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase.
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Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A VirusOne health, multiple challenges: The inter-species transmission of influenza A virusAnalysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.Virus-specific factors associated with zoonotic and pandemic potential.Risk assessment of H2N2 influenza viruses from the avian reservoirPB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.Conserved features of the PB2 627 domain impact influenza virus polymerase function and replicationPandemic potential of avian influenza A (H7N9) viruses.Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human CellsA comparative study of short linear motif compositions of the influenza A virus ribonucleoproteinsAdaptation of avian influenza A virus polymerase in mammals to overcome the host species barrierHuman-like PB2 627K influenza virus polymerase activity is regulated by importin-α1 and -α7.The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication.Quantifying the fitness advantage of polymerase substitutions in Influenza A/H7N9 viruses during adaptation to humans.Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.Global and quantitative proteomic analysis of dogs infected by avian-like H3N2 canine influenza virus.Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes.Investigation of influenza virus polymerase activity in pig cells.The RNA-dependent RNA polymerase of the influenza A virus.Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells.Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.The nuclear import machinery is a determinant of influenza virus host adaptation.Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.
P2860
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P2860
Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Influence of PB2 host-range de ...... influenza A virus polymerase.
@en
type
label
Influence of PB2 host-range de ...... influenza A virus polymerase.
@en
prefLabel
Influence of PB2 host-range de ...... influenza A virus polymerase.
@en
P2093
P2860
P356
P1476
Influence of PB2 host-range de ...... influenza A virus polymerase.
@en
P2093
Eva M Loucaides
Helen M Wise
Manuela Mura
Ágnes Foeglein
P2860
P304
P356
10.1099/VIR.0.031492-0
P407
P577
2011-04-06T00:00:00Z