Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase.
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Kinetic comparison of tissue non-specific and placental human alkaline phosphatases expressed in baculovirus infected cells: application to screening for Down's syndromeTargeting the active site of the placental isozyme of alkaline phosphatase by phage-displayed scFv antibodies selected by a specific uncompetitive inhibitorCrystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificityRefined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral siteNovel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP).Function assignment to conserved residues in mammalian alkaline phosphatases.Structural evidence of functional divergence in human alkaline phosphatases.Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymesCatalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.Functional significance of calcium binding to tissue-nonspecific alkaline phosphataseProduction of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro.Alkaline Phosphatase and Hypophosphatasia.Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract.Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells.Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells.Phosphate binding in the active site of alkaline phosphatase and the interactions of 2-nitrosoacetophenone with alkaline phosphatase-induced small structural changes.Distinct metal ion requirements for the phosphomonoesterase and phosphodiesterase activities of calf intestinal alkaline phosphataseBiology of human alkaline phosphatases with special reference to cancer.Distinct structure and activity recoveries reveal differences in metal binding between mammalian and Escherichia coli alkaline phosphatases.Structure-function analysis of human glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1a.Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.Cloning and expression of the bovine intestinal alkaline phosphatase gene: biochemical characterization of the recombinant enzyme.Differential autophosphorylation of CaM kinase II from phasic and tonic smooth muscle tissues.Purification and characterization of Ulva pertusa Kjellm alkaline phosphatase.Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures.Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases.Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.Simultaneous retention of thermostability and specific activity in chimeric human alkaline phosphatases.
P2860
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P2860
Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Molecular mechanism of uncompe ...... erm-cell alkaline phosphatase.
@en
type
label
Molecular mechanism of uncompe ...... erm-cell alkaline phosphatase.
@en
prefLabel
Molecular mechanism of uncompe ...... erm-cell alkaline phosphatase.
@en
P2093
P2860
P356
P1433
P1476
Molecular mechanism of uncompe ...... erm-cell alkaline phosphatase.
@en
P2093
J L Millán
M F Hoylaerts
P2860
P356
10.1042/BJ2860023
P407
P478
286 ( Pt 1)
P577
1992-08-01T00:00:00Z