Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.
about
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeletonThe Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogasterRequirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesisA novel muscle LIM-only protein is generated from the paxillin gene locus in DrosophilaSignalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt.CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.A misexpression screen to identify regulators of Drosophila larval hemocyte development.Targeted gain-of-function screening in Drosophila using GAL4-UAS and random transposon insertions.Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancerDrosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth.The small GTPase Rap1 is a modulator of Hedgehog signaling.Reciprocal Negative Regulation between the Guanine Nucleotide Exchange Factor C3G and β-Catenin.The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases.Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.
P2860
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P2860
Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Activation of the Drosophila C ...... the RAS-MAPK pathway and RAP1.
@en
type
label
Activation of the Drosophila C ...... the RAS-MAPK pathway and RAP1.
@en
prefLabel
Activation of the Drosophila C ...... the RAS-MAPK pathway and RAP1.
@en
P2093
P2860
P356
P1433
P1476
Activation of the Drosophila C ...... the RAS-MAPK pathway and RAP1.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/18.1.145
P407
P577
1999-01-01T00:00:00Z