pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum.
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Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.The interplay between drug resistance and fitness in malaria parasitesArtemisinins: their growing importance in medicineModulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugsChloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparumTransmission intensity and drug resistance in malaria population dynamics: implications for climate changeResistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitnessMetabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolismNo seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used.Competition between Plasmodium falciparum strains in clinical infections during in vitro culture adaptationDynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum.Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemicMalaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes.Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants.Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum.Various pfcrt and pfmdr1 genotypes of Plasmodium falciparum cocirculate with P. malariae, P. ovale spp., and P. vivax in northern Angola.Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.Antimalarial drug resistance: a review of the biology and strategies to delay emergence and spreadProspects for the treatment of drug-resistant malaria parasites.A combined within-host and between-hosts modelling framework for the evolution of resistance to antimalarial drugsDrug-resistant malaria - an insight.Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan ParasitesIn vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaImpaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies.Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in UgandaDrug-resistant malaria: molecular mechanisms and implications for public health.Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race.Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand.Clinically immune hosts as a refuge for drug-sensitive malaria parasites.pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies.Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic crossDeamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitroMeasuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia.Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda.Quantitative dissection of clone-specific growth rates in cultured malaria parasites.Superinfection and the evolution of resistance to antimalarial drugs.
P2860
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P2860
pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
pfmdr1 mutations associated wi ...... cost in Plasmodium falciparum.
@en
type
label
pfmdr1 mutations associated wi ...... cost in Plasmodium falciparum.
@en
prefLabel
pfmdr1 mutations associated wi ...... cost in Plasmodium falciparum.
@en
P2860
P921
P1476
pfmdr1 mutations associated wi ...... cost in Plasmodium falciparum.
@en
P2093
Rhys Hayward
P2860
P304
P356
10.1111/J.1365-2958.2004.04470.X
P407
P577
2005-02-01T00:00:00Z