about
Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interactionDNA damage tolerance by recombination: Molecular pathways and DNA structuresCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisDNA secondary structure at chromosomal fragile sites in human disease.Spectrum and consequences of SMC1A mutations: the unexpected involvement of a core component of cohesin in human disease.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.Genome-wide DNA methylation analysis in cohesin mutant human cell lines.DNA instability at chromosomal fragile sites in cancerPremature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication.RAD21 mutations cause a human cohesinopathyProteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes.Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16DThe biological effects of simple tandem repeats: lessons from the repeat expansion diseases.The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance.Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNAReplication fork recovery and regulation of common fragile sites stability.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Chromosome Dynamics during Mitosis.Genome stability: What we have learned from cohesinopathies.Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering.Fragile sites in cancer: more than meets the eye.Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins.Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and TumorigenesisSMC1A knockdown induces growth suppression of human lung adenocarcinoma cells through G1/S cell cycle phase arrest and apoptosis pathways in vitro.Imbalance of SMC1 and SMC3 cohesins causes specific and distinct effectsWerner syndrome helicase activity is essential in maintaining fragile site stability.FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage.X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations.The Detection and Analysis of Chromosome Fragile Sites.Mutant cohesin drives chromosomal instability in early colorectal adenomas.Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
SMC1 involvement in fragile site expression.
@en
type
label
SMC1 involvement in fragile site expression.
@en
prefLabel
SMC1 involvement in fragile site expression.
@en
P2093
P356
P1476
SMC1 involvement in fragile site expression
@en
P2093
Cristina Montagna
Esterina Indino
Lorenzo Brait
Luciana Chessa
Manuela Tilenni
Maria Luisa Focarelli
Paolo Vezzoni
Pier Alberto Benedetti
Thomas Ried
Tullio Mariani
P304
P356
10.1093/HMG/DDI049
P577
2005-01-07T00:00:00Z