Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking.
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The HTLV-1 Tax interactomeThe bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcriptionTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeatsSpecific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complexRole of Tax protein in human T-cell leukemia virus type-I leukemogenicityCREB--a real culprit in oncogenesisMolecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcriptionMolecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4).The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.Insight into the tumor suppressor function of CBP through the viral oncoprotein tax.The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerizationHuman T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription.p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function.The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expressionHuman T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis.Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation.Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1.Transcription regulatory complexes bind the human T-cell leukemia virus 5' and 3' long terminal repeats to control gene expression.Tax abolishes histone H1 repression of p300 acetyltransferase activity at the human T-cell leukemia virus type 1 promoter.Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independentHuman T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.Human T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription.An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZMolecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300.The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoterCCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA.In vivo genomic footprinting of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat enhancer sequences in HTLV-1-infected human T-cell lines with different levels of Tax I activity.SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax.Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes.Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control.Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex.Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells.Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis.Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation.
P2860
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P2860
Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Specific regions of contact be ...... ntified by photocross-linking.
@en
type
label
Specific regions of contact be ...... ntified by photocross-linking.
@en
prefLabel
Specific regions of contact be ...... ntified by photocross-linking.
@en
P2860
P356
P1476
Specific regions of contact be ...... ntified by photocross-linking.
@en
P2093
P2860
P304
13768-13775
P356
10.1074/JBC.273.22.13768
P407
P577
1998-05-01T00:00:00Z