A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
about
T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic miceFunctional profile of the human fetal gamma-globin gene upstream promoter region.A single-base substitution in the proximal Sp1 site of the human low density lipoprotein receptor promoter as a cause of heterozygous familial hypercholesterolemia.Exhaustive mutation scanning by fluorescence-assisted mismatch analysis discloses new genotype-phenotype correlations in angiodemaSp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpressionGene expression during erythropoiesis.Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element.Regulated expression of human alpha- and beta-globin genes in transient heterokaryonsThe transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (HCK) gene through binding to two adjacent GC boxes within the HCK promoter-proximal region.The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Analysis of the mechanism of action of the Brazilian type (Agamma-195 C --> G) of hereditary persistence of fetal hemoglobin.Modulation of the phenotypic diversity of sickle cell anemia.Synergistic activation of a human promoter in vivo by transcription factor Sp1.A variant Sp1 (R218Q) transcription factor might enhance HbF expression in β0 -thalassaemia homozygotes.GγAγ(β+) hereditary persistence of fetal hemoglobin: TheGγ – 158 C → T mutation incis to the − 175 T → C mutation of theAγ-globin gene results in increasedGγ-globin synthesis
P2860
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P2860
A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
description
1990 nî lūn-bûn
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1990年の論文
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年學術文章
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1990年學術文章
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name
A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
@en
type
label
A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
@en
prefLabel
A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
@en
P2860
P356
P1476
A naturally occurring gamma globin gene mutation enhances SP1 binding activity.
@en
P2093
P2860
P304
P356
10.1128/MCB.10.1.95
P407
P577
1990-01-01T00:00:00Z