Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.
about
The proprotein convertases and their implication in sterol and/or lipid metabolismAminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses.Novel approaches in anti-arenaviral drug developmentWhat lies ahead for the proprotein convertases?Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease.Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.Reverse genetics approaches to combat pathogenic arenavirusesZymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease.PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242.Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions.The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors.Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells.Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradationThe PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol.Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.
P2860
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P2860
Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Development of protein-based i ...... TF6, and a viral glycoprotein.
@en
type
label
Development of protein-based i ...... TF6, and a viral glycoprotein.
@en
prefLabel
Development of protein-based i ...... TF6, and a viral glycoprotein.
@en
P2860
P356
P1476
Development of protein-based i ...... TF6, and a viral glycoprotein.
@en
P2093
Martin Vincent
Philomena Pullikotil
P2860
P304
17338-17347
P356
10.1074/JBC.M313764200
P407
P577
2004-02-16T00:00:00Z