The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationThe proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsFurin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytesBeta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furinEndoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7Neuroendocrine secretory protein 7B2: structure, expression and functionsCleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infectionProprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipaseBinding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturationThe secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesisThe proprotein convertases and their implication in sterol and/or lipid metabolismImplication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptidesHepatic proprotein convertases modulate HDL metabolismEnzymatic activity of sperm proprotein convertase is important for mammalian fertilizationBiosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegmentInhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.In vitro elucidation of substrate specificity and bioassay of proprotein convertase 4 using intramolecularly quenched fluorogenic peptides.Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation.HreP, an in vivo-expressed protease of Yersinia enterocolitica, is a new member of the family of subtilisin/kexin-like proteasesIs there a link between proprotein convertase PC7 activity and human lipid homeostasis?Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function.PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.Polyphenols as therapeutic molecules in Alzheimer's disease through modulating amyloid pathways.Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.Proprotein convertase inhibition: Paralyzing the cell's master switches.pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.Structure-function analysis of the prosegment of the proprotein convertase PC5A.Propeptides as modulators of functional activity of proteases.Prosegment of tripeptidyl peptidase I is a potent, slow-binding inhibitor of its cognate enzyme.Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
P2860
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P2860
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The prosegments of furin and P ...... their efficacy and selectivity
@ast
The prosegments of furin and P ...... their efficacy and selectivity
@en
The prosegments of furin and P ...... their efficacy and selectivity
@en-gb
The prosegments of furin and P ...... their efficacy and selectivity
@nl
type
label
The prosegments of furin and P ...... their efficacy and selectivity
@ast
The prosegments of furin and P ...... their efficacy and selectivity
@en
The prosegments of furin and P ...... their efficacy and selectivity
@en-gb
The prosegments of furin and P ...... their efficacy and selectivity
@nl
prefLabel
The prosegments of furin and P ...... their efficacy and selectivity
@ast
The prosegments of furin and P ...... their efficacy and selectivity
@en
The prosegments of furin and P ...... their efficacy and selectivity
@en-gb
The prosegments of furin and P ...... their efficacy and selectivity
@nl
P2093
P356
P1476
The prosegments of furin and P ...... their efficacy and selectivity
@en
P2093
J S Munzer
M Chrétien
N G Seidah
S Benjannet
P304
P356
10.1074/JBC.274.48.33913
P407
P577
1999-11-26T00:00:00Z