Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
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Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapyA novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385The structure of NS-398 bound to cyclooxygenase-2The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosaRole of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitorsThromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardiaSpatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.Developmental expression of functional cyclooxygenases in zebrafish.Dual role of cyclooxygenase-2 during tissue repair induced by low level laser therapy: an intriguing issue.A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayerBiochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors.Cyclooxygenase-2 and its regulation in inflammation.The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 InhibitorRecent developments in chimeric NSAIDs as safer anti-inflammatory agents.Human scavenger receptor B1 is involved in recognition of apoptotic thymocytes by thymic nurse cells.Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus.RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion.Leishmania donovani-induced macrophages cyclooxygenase-2 and prostaglandin E2 synthesis.Kinetic basis for selective inhibition of cyclo-oxygenasesCyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2.Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2.Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol.Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation.Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations.Comparison of structural stabilities of prostaglandin H synthase-1 and -2.
P2860
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P2860
Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Role of Val509 in time-depende ...... y by isoform-selective agents.
@en
type
label
Role of Val509 in time-depende ...... y by isoform-selective agents.
@en
prefLabel
Role of Val509 in time-depende ...... y by isoform-selective agents.
@en
P2093
P2860
P356
P1476
Role of Val509 in time-depende ...... y by isoform-selective agents.
@en
P2093
P2860
P304
19134-19139
P356
10.1074/JBC.271.32.19134
P407
P577
1996-08-01T00:00:00Z