Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.
about
Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degenerationFog2 is required for normal diaphragm and lung development in mice and humansVACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging techniqueEfficient gene-driven germ-line point mutagenesis of C57BL/6J miceA Sox10 expression screen identifies an amino acid essential for Erbb3 function.THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in ciliaTtc21b is required to restrict sonic hedgehog activity in the developing mouse forebrainMouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathwayGenome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental diseaseLethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesPrdm16 is required for normal palatogenesis in mice.Analysis of mouse embryonic patterning and morphogenesis by forward geneticsIdentification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesisA forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutationsThe expanding role of mouse genetics for understanding human biology and diseaseExploiting the power of LINE-1 retrotransposon mutagenesis for identification of genes involved in embryonic stem cell differentiation.Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development.Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.Modifier screens in the mouse: time to move forward with reverse genetics.N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.ENU Mutagenesis in the Mouse.Genome-wide identification of mouse congenital heart disease loci.Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney diseaseDownregulating hedgehog signaling reduces renal cystogenic potential of mouse modelsUtilization of a whole genome SNP panel for efficient genetic mapping in the mouse.Coupled mutagenesis screens and genetic mapping in zebrafish.TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.The mouse MC13 mutant is a novel ENU mutation in collagen type II, alpha 1Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis.Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins.Technical approaches for mouse models of human diseaseFocusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouseAn integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities.
P2860
Q21092441-F9E25AB4-14B0-42BC-94DE-9B1D1D277456Q21145284-789E5F6F-22BB-4290-8D5A-79C373E8336FQ24318787-258E4686-514B-4FED-8A6A-B4724AE8F2AEQ24808964-1284AAE0-EC75-4B1E-88E2-3D99BBFBE477Q25255702-7582D6C5-B7BC-4FCE-89D1-7D085A506325Q28473562-2FC16685-2B76-4439-98C5-D8027A9991DAQ28505803-696EE415-F344-40DB-8936-769BA8BC830DQ28505900-F84E097C-FBAA-4FE8-A1DD-44B0AF022C37Q28507114-CA1ECF3D-8663-4AD9-8D5D-9A5E3525B87DQ28509829-965E9736-EF20-4754-A266-73F770D496F4Q28511992-75E955D1-0192-48F1-9F89-12D9A58DA452Q28585520-BDD53749-242C-4FEE-BE80-CAC8B17BE372Q28588157-87179983-01FF-412E-802D-1B1E1CC7AAA5Q28589055-6DD0D713-DE1F-4538-BD79-D64C04716339Q28589778-D5BEE11E-FAA9-4E15-8CE9-255A11F5D47AQ30433445-82A52651-7B56-4554-BB5B-CB73DCA9EE6BQ30502995-BC4B3C3A-72DB-47FC-B2ED-FA406C21766FQ33388684-ECDCEF32-ED4B-4D7C-853A-C64986E7DAD4Q33561315-31B09366-1908-45A2-8B33-1F9387F933A3Q33695715-3AC7D99E-1DF5-4510-9B80-C0E03AEDF649Q33759166-DDE8D3C4-B6EE-44FE-952B-B55C98091A80Q33778737-200F555F-CEAD-4B03-9794-9FF42916C864Q33825000-B9D7E890-DBE3-4B74-AF1A-215291C27A78Q33895030-FE46B4FD-39A8-4A34-B0BF-91FAC8BA0B75Q33903868-1BB5D8B1-F0A7-49F7-9D03-97AECC1CDFE7Q33940306-7B7DD7A1-5C99-404C-8E9B-6EC986826798Q33964080-E7CE9FA5-0BD1-48C3-94C1-568D27645087Q34013514-E1F1C88C-5938-415E-97B3-B796187B91FBQ34056378-F307B6D8-0687-431C-99E2-283EA69E86DAQ34260011-DAA9EE43-32B9-440D-B899-5349E82E6B95Q34483116-AE480E9B-3655-4E5A-8094-1A44C09D9270Q34617164-C47675ED-96B7-40E5-AA2B-7F3CA53AFA6EQ34764702-406A4261-C1E0-4FDB-A5AE-3D5B0672BD70Q34777036-9C2CC800-947F-417F-BBE1-B00E370E24B2Q34819274-434B5F4E-2513-4EB8-B222-8BCFD506FC38Q34837480-3BDD622A-D3E9-44BF-83AA-49D5BEB28EC3Q34990916-6F039A2C-1077-4C14-8274-B37950542E50Q35222725-7AE292CC-A4CF-409B-9D73-CABBEF7CCE46Q35349869-A5E81192-495A-4A4F-A398-514778E53F4DQ35552582-F48AD3CD-A108-4A95-B81D-6358AEB3686F
P2860
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Efficient generation and mappi ...... tations using ENU mutagenesis.
@en
type
label
Efficient generation and mappi ...... tations using ENU mutagenesis.
@en
prefLabel
Efficient generation and mappi ...... tations using ENU mutagenesis.
@en
P2093
P356
P1433
P1476
Efficient generation and mappi ...... tations using ENU mutagenesis.
@en
P2093
Bruce J Herron
Cherie Rao
David R Beier
Heiko Peters
J David McDonald
Monica J Justice
Roderick T Bronson
Shanming Liu
P2888
P304
P356
10.1038/NG812
P407
P50
P577
2002-01-02T00:00:00Z