Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
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pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epitheliaA requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionAccelerating aging by mouse reverse genetics: a rational approach to understanding longevityThe epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasisThe breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cellsConditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: do they play a role in ovarian carcinogenesis?Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damageThe inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors.MTA1-mediated transcriptional repression of BRCA1 tumor suppressor genePARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?Array-CGH and breast cancer.Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cellsHeregulin-dependent delay in mitotic progression requires HER4 and BRCA1.The changing role of pathology in breast cancer diagnosis and treatment.Genetically engineered mice as experimental tools to dissect the critical events in breast cancerA deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.Constitutional and acquired autosomal aneuploidyThe landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanineThe promise of genetically engineered mice for cancer prevention studies.Genomic analyses as a guide to target identification and preclinical testing of mouse models of breast cancerMolecular cytogenetics of mouse models of breast cancerTechnical challenges and limitations of current mouse models of ovarian cancer.Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1.Spectral karyotyping of human, mouse, rat and ape chromosomes--applications for genetic diagnostics and research.Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.Spectral karyotyping analysis of human and mouse chromosomes.Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer.Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component.BRCA1 in the DNA damage response and at telomeresA mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical modelsThe landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells.Revised karyotyping and gene mapping of the Biomphalaria glabrata embryonic (Bge) cell line.The epigenetic origin of aneuploidy.Unsolved mystery: the role of BRCA1 in DNA end-joining.
P2860
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P2860
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Mammary tumors in mice conditi ...... imilar to human breast cancer.
@en
type
label
Mammary tumors in mice conditi ...... imilar to human breast cancer.
@en
prefLabel
Mammary tumors in mice conditi ...... imilar to human breast cancer.
@en
P2093
P2860
P356
P1433
P1476
Mammary tumors in mice conditi ...... imilar to human breast cancer.
@en
P2093
Chu-Xia Deng
Cristina Montagna
Massimo Gadina
Steven G Brodie
Tamara Howard
Thomas Ried
Xiaoling Xu
Zoë Weaver
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205636
P407
P577
2002-08-01T00:00:00Z
P5875
P6179
1012614188