Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. - Wikidata - awgldk - TriplyDB

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.

http://www.wikidata.org/entity/Q38494989

about

Epithelial-mesenchymal transition and its implications for fibrosis The basics of epithelial-mesenchymal transition Matrix metalloproteinases in kidney homeostasis and diseases The wound healing, chronic fibrosis, and cancer progression triad Cardiac matrix: a clue for future therapy Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway.Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway VEGF ameliorates tubulointerstitial fibrosis in unilateral ureteral obstruction mice via inhibition of epithelial-mesenchymal transition Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial-mesenchymal transition Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells.Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition.Hypoxia-induced Bmi1 promotes renal tubular epithelial cell-mesenchymal transition and renal fibrosis via PI3K/Akt signal tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells.Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice.Epigallocatechin-3-gallate attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis in mice.Matrix metalloproteinase-9 expression is enhanced in renal parietal epithelial cells of zucker diabetic Fatty rats and is induced by albumin in in vitro primary parietal cell culture Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD.Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis.Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction.Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis.Inhibition of Thrombin-Activated Fibrinolysis Inhibitor Increases Survival in Experimental Kidney Fibrosis.Cellular and molecular mechanisms of renal fibrosis.Renal interstitial fibrosis: mechanisms and evaluation.New insights into epithelial-mesenchymal transition in kidney fibrosis.Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling Obstructive nephropathy: insights from genetically engineered animals.Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis.Epigenetic regulation of BMP7 in the regenerative response to ischemia.Early epithelial phenotypic changes predict graft fibrosis.PAI-1 and kidney fibrosis.

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P2860

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.

http://www.wikidata.org/entity/Q38494989

description

2002 nî lūn-bûn

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Disruption of tissue-type plas ...... is in obstructive nephropathy.

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Disruption of tissue-type plas ...... is in obstructive nephropathy.

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Disruption of tissue-type plas ...... is in obstructive nephropathy.

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Journal of Clinical Investigation

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Disruption of tissue-type plas ...... is in obstructive nephropathy.

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P2093

Chunsun Dai

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Junwei Yang

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Kari Nejak

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Rodney E Wegner

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Ryan W Shultz

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Wendy M Mars

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Yingjian Li

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Youhua Liu

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P2860

Molecular cloning and expression of human hepatocyte growth factor

Discovery of potent, achiral matrix metalloproteinase inhibitors

Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor

Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Recovery following relief of unilateral ureteral obstruction in the neonatal rat.

Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood.

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.

Recovery from release of ureteral obstruction in the rat: relationship to nephrogenesis.

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1525-1538

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10.1172/JCI0216219

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10

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110

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12438450

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151817

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