about
The associations between Parkinson's disease and cancer: the plot thickensLRRK2 at the interface of autophagosomes, endosomes and lysosomesPhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesG2385R and I2020T Mutations Increase LRRK2 GTPase ActivityAn additional k-means clustering step improves the biological features of WGCNA gene co-expression networks.Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein PathologyCryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.Recombinant Antibody Fragments for Neurodegenerative Diseases.Selective neuronal vulnerability in Parkinson disease.Models of LRRK2-Associated Parkinson's Disease.A systems biology-led insight into the role of the proteome in neurodegenerative diseases.LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease.Impaired intracortical transmission in G2019S leucine rich-repeat kinase Parkinson patients.Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders.Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits?LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
LRRK2 Pathways Leading to Neurodegeneration.
@en
type
label
LRRK2 Pathways Leading to Neurodegeneration.
@en
prefLabel
LRRK2 Pathways Leading to Neurodegeneration.
@en
P2860
P1476
LRRK2 Pathways Leading to Neurodegeneration.
@en
P2860
P2888
P356
10.1007/S11910-015-0564-Y
P577
2015-07-01T00:00:00Z
P6179
1029998455