An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation.
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Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cellsPacemaker Created in Human Ventricle by Depressing Inward-Rectifier K⁺ Current: A Simulation StudyIonic mechanisms of arrhythmogenesisAn LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardiaThe mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes.Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.Beat-to-beat cycle length variability of spontaneously beating guinea pig sinoatrial cells: relative contributions of the membrane and calcium clocks.From two competing oscillators to one coupled-clock pacemaker cell systemBurst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.Chronotropic Modulation of the Source-Sink Relationship of Sinoatrial-Atrial Impulse Conduction and Its Significance to Initiation of AF: A One-Dimensional Model Study.Modern perspectives on numerical modeling of cardiac pacemaker cellRyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.Mechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity.New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsSelective and specific inhibition of If with ivabradine for the treatment of coronary artery disease or heart failure.The destiny of Ca(2+) released by mitochondria.ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials.Computational analysis of the human sinus node action potential: model development and effects of mutations.Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytesA computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions.I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytesInterbeat interval modulation in the sinoatrial node as a result of membrane current stochasticity-a theoretical and numerical studyCa(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.Towards computational modelling of the human foetal electrocardiogram: normal sinus rhythm and congenital heart block.In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy.
P2860
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P2860
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
An updated computational model ...... isms of heart rate modulation.
@en
type
label
An updated computational model ...... isms of heart rate modulation.
@en
prefLabel
An updated computational model ...... isms of heart rate modulation.
@en
P2093
P2860
P1476
An updated computational model ...... isms of heart rate modulation.
@en
P2093
Lara A Charawi
Matteo Fantini
Stefano Severi
P2860
P304
P356
10.1113/JPHYSIOL.2012.229435
P407
P577
2012-06-18T00:00:00Z