Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesExploring the ATP-binding site of P2X receptorsPrinciples and properties of ion flow in P2X receptorsIdentification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.Agonist antagonist interactions at the rapidly desensitizing P2X3 receptorAgonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules.Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.Spinal astrocytes produce and secrete dynorphin neuropeptides.Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.Structural and molecular modeling features of P2X receptors.Emerging approaches to probing ion channel structure and function.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.P2X Receptor Activation.Modeling Interactions among Individual P2 Receptors to Explain Complex Response Patterns over a Wide Range of ATP Concentrations.The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitionsMass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner.
P2860
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P2860
Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cysteine scanning mutagenesis ...... ist binding and channel gating
@en
type
label
Cysteine scanning mutagenesis ...... ist binding and channel gating
@en
prefLabel
Cysteine scanning mutagenesis ...... ist binding and channel gating
@en
P2093
P2860
P356
P1476
Cysteine scanning mutagenesis ...... ist binding and channel gating
@en
P2093
Ralf Schmid
Rebecca C Allsopp
Richard J Evans
Sam El Ajouz
P2860
P304
29207-29217
P356
10.1074/JBC.M111.260364
P407
P50
P577
2011-06-20T00:00:00Z