Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug DesignCrystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma bruceiIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziMining a cathepsin inhibitor library for new antiparasitic drug leadsCathepsin-L can resist lysis by human serum in Trypanosoma brucei bruceiA Pre-clinical Animal Model of Trypanosoma brucei Infection Demonstrating Cardiac DysfunctionModulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African TrypanosomesSubstrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages.RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning.Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.Secretory pathway of trypanosomatid parasites.Congopain from Trypanosoma congolense: drug target and vaccine candidate.Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei.Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo.Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal ActivityHost-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Novel antitrypanosomal agents.A determination of the steady state lysosomal pH of bloodstream stage African trypanosomes.African Trypanosome-Induced Blood-Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation.Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.A parasite cysteine protease is key to host protein degradation and iron acquisition.Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.Host-parasite interactions in trypanosomiasis: on the way to an antidisease strategy.A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infectionTrypanocidal drugs: mechanisms, resistance and new targets.Cathepsin proteases in Toxoplasma gondii.High-throughput decoding of antitrypanosomal drug efficacy and resistance.Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents.Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes.A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatBSquamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases.The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.
P2860
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P2860
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Active site mapping, biochemic ...... rypanosoma brucei rhodesiense.
@en
type
label
Active site mapping, biochemic ...... rypanosoma brucei rhodesiense.
@en
prefLabel
Active site mapping, biochemic ...... rypanosoma brucei rhodesiense.
@en
P2093
P1476
Active site mapping, biochemic ...... rypanosoma brucei rhodesiense.
@en
P2093
Alvarez Hernandez A
Caffrey CR
Gwaltney SL 2nd
McKerrow JH
P356
10.1016/S0166-6851(01)00368-1
P577
2001-11-01T00:00:00Z