Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

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M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.

P2860

Q46956989-C2F7B828-47B9-4F82-B827-B929973D2A1E

P2860

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

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http://www.wikidata.org/entity/Q38944062

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

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2017年學術文章

@yue

2017年學術文章

@zh

2017年學術文章

@zh-hant

name

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

@en

type

Item

label

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

@en

prefLabel

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

@en

P1476

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

@en

P2093

Chen Hu

http://www.w3.org/2001/XMLSchema#string

Junjie Xu

http://www.w3.org/2001/XMLSchema#string

Linlin Zeng

http://www.w3.org/2001/XMLSchema#string

Ting Li

http://www.w3.org/2001/XMLSchema#string

Xuemin Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals

P304

1263-1269

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P31

scholarly article

P356

10.3233/JAD-161094

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Mei-Zhen Cui

P577

2017-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28234257

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P932

5644992

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Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

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P2860

P2860

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

description

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type

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prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932