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Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax proteinBoth the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAPThe same gamma-secretase accounts for the multiple intramembrane cleavages of APPIdentification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migrationCellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteinsEffects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical modelThe GxxxG motif in the transmembrane domain of AbetaPP plays an essential role in the interaction of CTF beta with the gamma-secretase complex and the formation of amyloid-betaPen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitmentLysophosphatidic acid induces increased BACE1 expression and Aβ formation.Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells.Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.Nanospherical arabinogalactan proteins are a key component of the high-strength adhesive secreted by English ivyMatricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration.Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21.CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation.Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.Lysophosphatidic acid effects on atherosclerosis and thrombosis.Distinct cell responses to substrates consisting of poly(ε-caprolactone) and poly(propylene fumarate) in the presence or absence of cross-links.Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation.gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain.Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells.Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells.The LIF response element of the alpha 2 macroglobulin gene confers LIF-induced transcriptional activation in embryonal stem cells.Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway.Potential therapeutics for myocardial ischemia-reperfusion injury. Focus on "Induction of cardioprotection by small netrin-1-derived peptides".Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.Lysophosphatidic acid induction of tissue factor expression in aortic smooth muscle cells.Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.Lysophosphatidic acid induces early growth response gene 1 expression in vascular smooth muscle cells: CRE and SRE mediate the transcription.Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1
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P50
description
researcher
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wetenschapper
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հետազոտող
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Mei-Zhen Cui
@ast
Mei-Zhen Cui
@en
Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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Mei-Zhen Cui
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P106
P1153
7103096884
P31
P496
0000-0003-4745-6999