Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. - Wikidata - awgldk - TriplyDB

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

http://www.wikidata.org/entity/Q39007648

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Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease Genome Engineering with TALE and CRISPR Systems in Neuroscience Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad Modeling ALS and FTD with iPSC-derived neurons Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency Transcription factor-mediated reprogramming toward hematopoietic stem cells Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model Modeling ALS with motor neurons derived from human induced pluripotent stem cells Inherited heart disease - what can we expect from the second decade of human iPS cell research?A perspective on stem cell modeling of amyotrophic lateral sclerosis Concise Review: Exciting Cells: Modeling Genetic Epilepsies with Patient-Derived Induced Pluripotent Stem Cells Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis.Modelling amyotrophic lateral sclerosis: progress and possibilities All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins Investigating human disease using stem cell models.An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+ Channels in Aplysia Neurons Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease.Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells.Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents.Advances in reprogramming-based study of neurologic disorders Connectivity and circuitry in a dish versus in a brain

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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

http://www.wikidata.org/entity/Q39007648

description

2014 nî lūn-bûn

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name

Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

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Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

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type

label

Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

@en

Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

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prefLabel

Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

@en

Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

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J.CELREP.2014.03.019

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Intrinsic membrane hyperexcita ...... patient-derived motor neurons.

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Brian J Wainger

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Bruce P Bean

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Cassidy Mellin

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Clifford J Woolf

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Evangelos Kiskinis

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Gabriella Boulting

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Jackson Sandoe

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James D Berry

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Kevin Eggan

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Luis A Williams

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P2860

Neural KCNQ (Kv7) channels

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes

'Rejuvenation' protects neurons in mouse models of Parkinson's disease

DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

SMN is required for sensory-motor circuit function in Drosophila.

Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

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1-11

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scholarly article

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10.1016/J.CELREP.2014.03.019

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1

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7

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Merit E Cudkowicz

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2014-04-03T00:00:00Z

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261406972

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24703839

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amyotrophic lateral sclerosis

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4023477

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