The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
about
A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging?The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancerExpression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladderCyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxiasPhenotypic research on senile osteoporosis caused by SIRT6 deficiency.Chromatin and beyond: the multitasking roles for SIRT6Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death.Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage.Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.SIRT6: Novel Mechanisms and Links to Aging and Disease.USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.Regulation of autophagic flux by CHIP.Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.CHIP as a membrane-shuttling proteostasis sensor.SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway.CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR.U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation.Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
P2860
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P2860
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@en
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@nl
type
label
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@en
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@nl
prefLabel
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@en
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@nl
P2093
P2860
P356
P1476
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
@en
P2093
Cam Patterson
Holly McDonough
Sarah M Ronnebaum
P2860
P304
P356
10.1128/MCB.00480-13
P407
P577
2013-09-16T00:00:00Z