Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression
about
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17The Mcm2-7 replicative helicase: a promising chemotherapeutic targetMammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phaseHbo1 Links p53-dependent stress signaling to DNA replication licensing.The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.Oncogenic protein MTBP interacts with MYC to promote tumorigenesisActivation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines.RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Analysis of re-replication from deregulated origin licensing by DNA fiber spreadingDisruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication.KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stressProhibitin physically interacts with MCM proteins and inhibits mammalian DNA replication.Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly.Mdmx promotes genomic instability independent of p53 and Mdm2.Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer.Cyclin D3 action in androgen receptor regulation and prostate cancer.RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
P2860
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P2860
Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Distinct action of the retinob ...... sembly and S-phase progression
@en
Distinct action of the retinob ...... embly and S-phase progression.
@nl
type
label
Distinct action of the retinob ...... sembly and S-phase progression
@en
Distinct action of the retinob ...... embly and S-phase progression.
@nl
prefLabel
Distinct action of the retinob ...... sembly and S-phase progression
@en
Distinct action of the retinob ...... embly and S-phase progression.
@nl
P2093
P2860
P356
P1476
Distinct action of the retinob ...... sembly and S-phase progression
@en
P2093
Emily Bosco
Erik S Knudsen
Jon M Lenihan
K Scott Luce
Michael F Reed
Wesley A Braden
William Zagorski
Zhengdao Lan
P2860
P304
P356
10.1128/MCB.00045-06
P407
P577
2006-08-14T00:00:00Z