Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity. - Wikidata - awgldk - TriplyDB

Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity.

Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity.

http://www.wikidata.org/entity/Q39175137

about

The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics Principles of antibody-mediated TNF receptor activation Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD.Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.Exogenous administration of a recombinant variant of TWEAK impairs healing after myocardial infarction by aggravation of inflammation.Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR.The TWEAK-Fn14 system as a potential drug target.Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo.Fn14 is regulated via the RhoA pathway and mediates nuclear factor-kappaB activation by Angiotensin II.TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic.TWEAK/Fn14 Activation Participates in Skin Inflammation.Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells Death receptor 3 signaling enhances proliferation of human regulatory T cells.Soluble TL1A is sufficient for activation of death receptor 3.

P2860

Q26795601-2B147FA5-65CA-4206-BCF3-65517AD9E968 Q26796270-FD73049C-FB55-47AB-91C1-012AA6EEA07B Q27347256-C38332F8-A4BC-4289-AFD9-A729C0E6EE5D Q33676528-346C53D7-87ED-4205-B413-D91A2A5E35EB Q34773994-4BCFDA69-561A-4B7C-A6F7-EE1E221D640D Q35954775-474F453A-409B-4B8E-8B05-C981182E12A5 Q36635311-0499D884-D370-4D1F-AA69-C58F5334DB5D Q37297728-45022676-8EA1-4728-BD62-D3D33788570E Q37446811-A30C212E-23B3-4C63-8284-351D3953D585 Q38129961-DECA2E5F-A92A-4628-973A-2916F94B4143 Q38135313-63D38835-1522-4257-A421-13B29C5CA670 Q38189358-325D53E0-4AD8-475F-9FEF-D485706061E5 Q39010178-3F25C903-C000-4F07-82D7-1A71354A689F Q39077360-EF26B705-3815-44C9-83D7-F66E58A91E13 Q40634005-57F10DA3-AD62-4CC3-9841-63D43C6734FB Q42004462-40AD93A4-716A-4D91-9B04-298BA922A700 Q42361200-A0F56F2C-CFDC-4D66-A618-EBC0868B0ACE Q42718215-6B8856AD-94B1-4418-AED6-8964D7EBB463 Q48366449-AD99BCF4-D0A3-4171-ABD6-DCE8EA82B6F8 Q52906317-BA0DFE4C-A2D7-4EF4-8BEA-9834F8A92F7A

P2860

Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity.

http://www.wikidata.org/entity/Q39175137

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Fibroblast growth factor induc ...... tic and antagonistic activity.

@en

Fibroblast growth factor inducible

@nl

type

label

Fibroblast growth factor induc ...... tic and antagonistic activity.

@en

Fibroblast growth factor inducible

@nl

prefLabel

Fibroblast growth factor induc ...... tic and antagonistic activity.

@en

Fibroblast growth factor inducible

@nl

P1433

Q39175137-FBCAAE71-6E05-41B0-9EA4-A0B86F9FF6F6

P1476

Q39175137-6EB71468-A04F-4828-8692-5310016849ED

P2093

Q39175137-4EAA8DE1-DA5F-40B0-A2D6-A8CE0539FD0C

Q39175137-6FECB35C-A852-4EE2-B2E5-F39EA2289A45

Q39175137-86F39315-C42F-411D-B8DC-91F3CCFCB8FA

Q39175137-AFEA3BD7-CC99-4430-9661-4C68578056ED

Q39175137-B48F8DF2-12DD-4AD4-B0AA-937D4C678009

Q39175137-EE7169F3-CB49-4BE1-9DCE-1917009959AD

P2860

Q39175137-0B5DA687-9668-4DD8-AC8C-1795617B301B

Q39175137-0E251653-F62C-425A-A592-354B3E3D37F8

Q39175137-0F3C45CD-740E-4110-B4F1-739DC11C06A9

Q39175137-123DFE28-F4B1-46C0-84E3-35F0A2E61DE2

Q39175137-272FA271-3223-4D53-B7D5-F2984063687B

Q39175137-4603808D-8F0A-456A-98A0-65FCDD928EE0

Q39175137-48B9EC6F-5A11-48B7-BBD5-B60ECFC50ADA

Q39175137-49947902-5675-41D3-95CF-6483A14520CB

Q39175137-59DA7152-AF13-4701-929F-2D81743827E7

Q39175137-5D9AAC72-4F57-433C-9266-38973041FDBD

P304

Q39175137-2E274E54-388F-40B7-BC79-8F3F26FFBF17

P31

Q39175137-A28ECC06-8C01-41F7-842C-5153FA782447

P356

Q39175137-A35884B7-BEBF-4A44-8E52-FA763768AC8C

P407

Q39175137-B88B1747-4C2C-41D4-AF1F-3CCCBE69F2F4

P433

Q39175137-B7C41FA0-52D2-4F6F-AD0F-3E58FBAC7E84

P478

Q39175137-EBAE83E4-2BE2-4C22-A749-B74AFA9A1130

P50

Q39175137-EE6CAD2E-B38B-4B1F-A038-2A8DE3916D0A

P577

Q39175137-6E1CC410-CA6A-4D32-BD0A-2BA022BDCB61

P698

Q39175137-822EDA0A-7853-4D02-9725-3191C8DD734B

P932

Q39175137-7B2D92D2-D351-441E-95FB-36353C26C493

P356

JBC.M112.435917

P1433

Journal of Biological Chemistry

P1476

Fibroblast growth factor induc ...... tic and antagonistic activity.

@en

P2093

Alevtina Rosenthal

http://www.w3.org/2001/XMLSchema#string

Axel Seher

http://www.w3.org/2001/XMLSchema#string

Daniela Siegmund

http://www.w3.org/2001/XMLSchema#string

Daniela Weisenberger

http://www.w3.org/2001/XMLSchema#string

Johannes Trebing

http://www.w3.org/2001/XMLSchema#string

Steffen Salzmann

http://www.w3.org/2001/XMLSchema#string

P2860

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8

Structural basis for self-association and receptor recognition of human TRAF2

The structural basis for the recognition of diverse receptor sequences by TRAF2

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice.

P304

13455-13466

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M112.435917

http://www.w3.org/2001/XMLSchema#string

P407

P433

19

http://www.w3.org/2001/XMLSchema#string

P478

288

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-03-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23532848

http://www.w3.org/2001/XMLSchema#string

P932

3650383

http://www.w3.org/2001/XMLSchema#string