Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence
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Endogenous opioid antagonism in physiological experimental pain models: a systematic reviewPositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsEndogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to HumanCommonalities between pain and memory mechanisms and their meaning for understanding chronic painGα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years laterEndogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7A critical time window for dopamine actions on the structural plasticity of dendritic spinesConstitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Pain control following inguinal herniorrhaphy: current perspectivesβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.Evolution: the advantage of 'maladaptive' pain plasticity.Nociceptor beta II, delta, and epsilon isoforms of PKC differentially mediate paclitaxel-induced spontaneous and evoked pain.Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.DNA Methylation Modulates Nociceptive Sensitization after Incision.Latent sensitization: a model for stress-sensitive chronic pain.Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.The pharmacology of nociceptor primingSustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive ActivityDisruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse.Neonatal Tissue Damage Promotes Spike Timing-Dependent Synaptic Long-Term Potentiation in Adult Spinal Projection Neurons.PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease modelEffects of target-controlled infusion of high-dose naloxone on pain and hyperalgesia in a human thermal injury model: a study protocol: A randomized, double-blind, placebo-controlled, crossover trial with an enriched design.Toll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation.Endogenous opioid inhibition of chronic low-back pain influences degree of back pain relief after morphine administration.Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.The vital role of constitutive GPCR activity in the mesolimbic dopamine system.Multipotent stromal cells for arthritic joint pain therapy and beyond.Management of persistent postsurgical inguinal pain.Endogenous analgesia, dependence, and latent pain sensitizationIdentifying ligands at orphan GPCRs: current status using structure-based approaches.Opioids and Chronic Pain: Where Is the Balance?In vivo immune interactions of multipotent stromal cells underlie their long-lasting pain-relieving effectNociceptor plasticity: A closer look.Constitutive Desensitization of Opioid Receptors in Peripheral Sensory Neurons.Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis.Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
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P2860
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
@zh-hant
name
Constitutive μ-opioid receptor ...... enous analgesia and dependence
@en
Constitutive μ-opioid receptor ...... nous analgesia and dependence.
@nl
type
label
Constitutive μ-opioid receptor ...... enous analgesia and dependence
@en
Constitutive μ-opioid receptor ...... nous analgesia and dependence.
@nl
prefLabel
Constitutive μ-opioid receptor ...... enous analgesia and dependence
@en
Constitutive μ-opioid receptor ...... nous analgesia and dependence.
@nl
P2093
P2860
P356
P1433
P1476
Constitutive μ-opioid receptor ...... enous analgesia and dependence
@en
P2093
B K Taylor
B L Jutras
J S Wieskopf
M K Winter
P2860
P304
P356
10.1126/SCIENCE.1239403
P407
P577
2013-09-01T00:00:00Z