about
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine groupMolecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid LeukemiaThe interaction between coumarin drugs and DNA gyraseIn vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerationsActivity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse modelEffect of mitonafide analogs on topoisomerase II of Leishmania chagasi.Purification of GidA protein, a novel topoisomerase II inhibitor produced by Streptomyces flavoviridis.Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22DNA topoisomerase-targeting antitumor drugs can be studied in yeastHuman DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.Modulation of gyrase-mediated DNA cleavage and cell killing by ATP.Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli.Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I.DNA gyrase: structure and function.Topoisomerase activity associated with SV40 large tumor antigen.Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp.Control of bacterial DNA supercoiling.Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agentsInhibitory effects of quinolones on pro- and eucaryotic DNA topoisomerases I and II.Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolonesUse of in vitro topoisomerase II assays for studying quinolone antibacterial agentsDNA repair functions that control sensitivity to topoisomerase-targeting drugsCoumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent.Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.Genetic transformation of the Lyme disease agent Borrelia burgdorferi with coumarin-resistant gyrBAdverse conditions which cause lack of flagella in Escherichia coliMechanism of adverse conditions causing lack of flagella in Escherichia coligyrB mutations in coumermycin A1-resistant Borrelia burgdorferiPreclinical evaluation of novel imidazoacridinone derivatives with potent activity against experimental colorectal cancerThe level of Z-DNA in metabolically active, permeabilized mammalian cell nuclei is regulated by torsional strain.Paranemic structures of DNA and their role in DNA unwinding.Lytic effect of two fluoroquinolones, ofloxacin and pefloxacin, on Escherichia coli W7 and its consequences on peptidoglycan composition.Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikoninIn vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations.DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs.Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependentNew strategy for overcoming resistance to chemotherapy of ovarian cancer.High-resolution mapping of mammalian genes by in situ hybridization to free chromatin.
P2860
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P2860
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Inhibitors of DNA topoisomerases.
@en
Inhibitors of DNA topoisomerases.
@nl
type
label
Inhibitors of DNA topoisomerases.
@en
Inhibitors of DNA topoisomerases.
@nl
prefLabel
Inhibitors of DNA topoisomerases.
@en
Inhibitors of DNA topoisomerases.
@nl
P356
P1433
P1476
Inhibitors of DNA topoisomerases.
@en
P2093
P304
P356
10.1021/BI00407A001
P407
P577
1988-04-01T00:00:00Z