Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
about
Bacteriophage T4 GenomeTargeting DNA topoisomerase II in cancer chemotherapyRole of minor groove width and hydration pattern on amsacrine interaction with DNASensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesionsInteraction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sitesAn antitumor drug-induced topoisomerase cleavage complex blocks a bacteriophage T4 replication fork in vivo.The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action.Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotidesDrug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalphaPosition-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.Positioning the 3'-DNA terminus for topoisomerase II-mediated religation.Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.In the presence of subunit A inhibitors DNA gyrase cleaves DNA fragments as short as 20 bp at specific sites.Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaksMapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.Apurinic sites are position-specific topoisomerase II poisons.
P2860
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P2860
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@ast
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@en
type
label
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@ast
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@en
prefLabel
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@ast
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@en
P2860
P356
P1476
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
@en
P2093
C H Freudenreich
K N Kreuzer
P2860
P304
11007-11011
P356
10.1073/PNAS.91.23.11007
P407
P577
1994-11-01T00:00:00Z