Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch. - Wikidata - awgldk - TriplyDB

Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.

Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.

http://www.wikidata.org/entity/Q37056420

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Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.Huannao Yicong Formula () regulates γ-secretase activity through APH-1 and PEN-2 gene ragulation pathways in hippocampus of APP/PS1 double transgenic mice.

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P2860

Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.

http://www.wikidata.org/entity/Q37056420

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 30 December 2015

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Nicastrin is required for APP ...... cessing of both APP and Notch.

@en

Nicastrin is required for APP ...... cessing of both APP and Notch.

@nl

type

label

Nicastrin is required for APP ...... cessing of both APP and Notch.

@en

Nicastrin is required for APP ...... cessing of both APP and Notch.

@nl

prefLabel

Nicastrin is required for APP ...... cessing of both APP and Notch.

@en

Nicastrin is required for APP ...... cessing of both APP and Notch.

@nl

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Journal of Neurochemistry

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Nicastrin is required for APP ...... cessing of both APP and Notch.

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P2093

Chen Hu

http://www.w3.org/2001/XMLSchema#string

Linlin Zeng

http://www.w3.org/2001/XMLSchema#string

Michael A Meyer

http://www.w3.org/2001/XMLSchema#string

Ting Li

http://www.w3.org/2001/XMLSchema#string

Xuemin Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

Trafficking regulation of proteins in Alzheimer's disease

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals

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1246-1258

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10.1111/JNC.13518

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26717550

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4929055

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