Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes. - Wikidata - awgldk - TriplyDB

Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.

Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.

http://www.wikidata.org/entity/Q39275355

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Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Key role of CRF in the skin stress response system.Adjuvant therapy with high dose vitamin D following primary treatment of melanoma at high risk of recurrence: a placebo controlled randomised phase II trial (ANZMTG 02.09 Mel-D).CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas.Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1 N1-Acetyl-5-Methoxykynuramine (AMK) is produced in the human epidermis and shows antiproliferative effects.Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation.Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.On the role of skin in the regulation of local and systemic steroidogenic activities.Expression of Vitamin D Receptor (VDR) Positively Correlates with Survival of Urothelial Bladder Cancer Patients.Total synthesis of biologically active 20S-hydroxyvitamin D3.Novel activities of CYP11A1 and their potential physiological significance.Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.Cytochromes p450 and skin cancer: role of local endocrine pathways.Novel vitamin D photoproducts and their precursors in the skin.On the role of environmental humidity on cortisol production by epidermal keratinocytes.Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs.In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.On the role of classical and novel forms of vitamin D in melanoma progression and management.Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR.Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols.Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.Vitamin D as an adjuvant in melanoma therapy.1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis.Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors

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P2860

Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.

http://www.wikidata.org/entity/Q39275355

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年學術文章

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Anticancer Research

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Novel vitamin D hydroxyderivat ...... effects on normal melanocytes.

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Adam C Wright

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Andrzej T Slominski

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Laura N Grese

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Minh N Nguyen

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Robert C Tuckey

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Samuel J Riney

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Tae-Kang Kim

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Zorica Janjetovic

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P2860

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells

New vitamin D analogs as potential therapeutics in melanoma

Vitamin D deficiency

Melanin pigmentation in mammalian skin and its hormonal regulation

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

Vitamin D metabolism and function in the skin.

Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression.

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