Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
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Steroidogenesis in the skin: implications for local immune functionsNew vitamin D analogs as potential therapeutics in melanomaCytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity.Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Key role of CRF in the skin stress response system.Elevated Autophagy and Mitochondrial Dysfunction in the Smith-Lemli-Opitz Syndrome.Lumisterol is metabolized by CYP11A1: discovery of a new pathwayNeuroendocrinology of the skin: An overview and selective analysis20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.Expression of vitamin D receptor decreases during progression of pigmented skin lesions.Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cellsCutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiationMetabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.On the role of skin in the regulation of local and systemic steroidogenic activities.A dermatologist's perspective on vitamin D.Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytesNovel activities of CYP11A1 and their potential physiological significance.Cytochromes p450 and skin cancer: role of local endocrine pathways.Novel vitamin D compounds and skin cancer prevention.Novel vitamin D photoproducts and their precursors in the skin.On the role of environmental humidity on cortisol production by epidermal keratinocytes.Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs.The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.On the role of classical and novel forms of vitamin D in melanoma progression and management.Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR.Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic.Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity.Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity.
P2860
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P2860
Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
description
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2009
@ast
im Januar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/01/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/01/01)
@nl
наукова стаття, опублікована в січні 2009
@uk
name
Sequential metabolism of 7-deh ...... ogical implication in the skin
@ast
Sequential metabolism of 7-deh ...... ogical implication in the skin
@en
Sequential metabolism of 7-deh ...... ogical implication in the skin
@nl
type
label
Sequential metabolism of 7-deh ...... ogical implication in the skin
@ast
Sequential metabolism of 7-deh ...... ogical implication in the skin
@en
Sequential metabolism of 7-deh ...... ogical implication in the skin
@nl
prefLabel
Sequential metabolism of 7-deh ...... ogical implication in the skin
@ast
Sequential metabolism of 7-deh ...... ogical implication in the skin
@en
Sequential metabolism of 7-deh ...... ogical implication in the skin
@nl
P2093
P2860
P3181
P1433
P1476
Sequential metabolism of 7-deh ...... ogical implication in the skin
@en
P2093
Andrzej T Slominski
Jordan K Zjawiony
Michal A Zmijewski
Trevor Sweatman
Zorica Janjetovic
P2860
P3181
P356
10.1371/JOURNAL.PONE.0004309
P407
P577
2009-02-03T00:00:00Z