Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh
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The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes.Interactive effects of cocaine on HIV infection: implication in HIV-associated neurocognitive disorder and neuroAIDSHIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesHIV Associated Neurocognitive DisordersBioinformatic analysis of HIV-1 entry and pathogenesis.The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitorDopamine receptor activation increases HIV entry into primary human macrophagesHuman immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophagesInteraction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolateGenetic variation and HIV-associated neurologic disease.Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophagesAdoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo.Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.HIV-1 replication in the central nervous system occurs in two distinct cell types.Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis.Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope.Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis.Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection.A single amino acid substitution in the C4 region in gp120 confers enhanced neutralization of HIV-1 by modulating CD4 binding sites and V3 loop.HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites.A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia.Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young childrenGenetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 alleleThe neuropathogenesis of feline immunodeficiency virus infection: barriers to overcomeGag regulates association of human immunodeficiency virus type 1 envelope with detergent-resistant membranes.Evidence that Vpu modulates HIV-1 Gag-envelope interaction towards envelope incorporation and infectivity in a cell type dependent manner.Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis.A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection.An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies.The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismIntercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitorsPharmacological induction of CCL5 in vivo prevents gp120-mediated neuronal injury.HIV-1 target cells in the CNS.HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages.Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.
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Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enh
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Biological analysis of human i ...... n the brain that confer an enh
@en
Biological analysis of human i ...... n the brain that confer an enh
@nl
type
label
Biological analysis of human i ...... n the brain that confer an enh
@en
Biological analysis of human i ...... n the brain that confer an enh
@nl
prefLabel
Biological analysis of human i ...... n the brain that confer an enh
@en
Biological analysis of human i ...... n the brain that confer an enh
@nl
P2093
P2860
P921
P1433
P1476
Biological analysis of human i ...... n the brain that confer an enh
@en
P2093
Jayanta Bhattacharya
Jeanne Bell
Matthias T Dittmar
Paul J Peters
Paul R Clapham
Peter Simmonds
Samantha Hibbitts
P2860
P304
P356
10.1128/JVI.78.13.6915-6926.2004
P407
P577
2004-07-01T00:00:00Z