PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
about
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionMultiple Roles of the Small GTPase Rab7Focus on PTEN RegulationPtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanismSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersTherapeutic targeting of cancers with loss of PTEN function.PTEN is a protein tyrosine phosphatase for IRS1PTEN regulates cilia through Dishevelled.The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activityRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesPTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesisPTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-The PTEN/NRF2 axis promotes human carcinogenesisThe protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation.Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomesPTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.PTEN function: the long and the short of it.Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies.Phosphatidylinositolphosphate phosphatase activities and cancer.Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activityNeomorphic mutations create therapeutic challenges in cancer.Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.PTEN regulates PLK1 and controls chromosomal stability during cell divisionPTEN ablation in Ras(Ha)/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition.miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma.Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.
P2860
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P2860
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@en
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@nl
type
label
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@en
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@nl
prefLabel
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@en
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@nl
P2093
P2860
P50
P1433
P1476
PTEN protein phosphatase activ ...... pe, but not with AKT activity.
@en
P2093
Georgios Zilidis
Helene Maccario
Laura Spinelli
Lindsay Davidson
Nevin M Perera
Nick Schurch
Priyanka Tibarewal
P2860
P356
10.1126/SCISIGNAL.2002138
P577
2012-02-28T00:00:00Z