Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. - Wikidata - awgldk - TriplyDB

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.

http://www.wikidata.org/entity/Q39451819

about

Building and remodelling Cullin-RING E3 ubiquitin ligases E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.Understanding cullin-RING E3 biology through proteomics-based substrate identification Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine.A fast workflow for identification and quantification of proteomes.TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.Posttranslational modifications of lysine and evolving role in heart pathologies-recent developments.MLN4924 therapy as a novel approach in cancer treatment modalities.Structurally related hydrazone-based metal complexes with different antitumor activities variably induce apoptotic cell death.NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization.Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice.Guard the guardian: A CRL4 ligase stands watch over histone production.Ubiquitination in melanoma pathogenesis and treatment.MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells.The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis.Synergistic anti-AML effects of the LSD1 inhibitor T-3775440 and the NEDD8-activating enzyme inhibitor pevonedistat via transdifferentiation and DNA rereplication.The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.Advancing cell biology through proteomics in space and time (PROSPECTS).FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death.

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Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.

http://www.wikidata.org/entity/Q39451819

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

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2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh

2011年學術文章

@zh-hant

name

Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

@en

Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

@nl

type

label

Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

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Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

@nl

prefLabel

Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

@en

Quantitative proteomic analysi ...... -activating enzyme by MLN4924.

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MCP.M111.009183

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Molecular & Cellular Proteomics

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Quantitative proteomic analysi ...... 8-activating enzyme by MLN4924

@en

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Eric S Lightcap

http://www.w3.org/2001/XMLSchema#string

Hua Liao

http://www.w3.org/2001/XMLSchema#string

Hugues Bernard

http://www.w3.org/2001/XMLSchema#string

Jonathan L Blank

http://www.w3.org/2001/XMLSchema#string

Khristofer Garcia

http://www.w3.org/2001/XMLSchema#string

Xiaozhen J Liu

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P2860

Cullin-RING ubiquitin ligases: global regulation and activation cycles

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

Ribosomal proteins are targets for the NEDD8 pathway

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Induction of cullin 7 by DNA damage attenuates p53 function

BRCA1 regulates p53-dependent gene expression

Statistics review 13: receiver operating characteristic curves

Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets.

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M111.009183

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scholarly article

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10.1074/MCP.M111.009183

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11

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10

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21873567

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3226404

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