Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growthThe RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaBStructural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complexRAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanismRegulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activityHSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivoCalmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human plateletsp21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cellsLoss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathwaysRal GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformationRal GTPases: crucial mediators of exocytosis and tumourigenesisThe Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic targetTranscriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.Immunogenicity of Ra1A and its tissue-specific expression in hepatocellular carcinoma.Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP).A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathwaysThe RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases.The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complexId2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway.Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infectionHonokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.Curcumin, a potential therapeutic candidate for retinal diseases.Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model.Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.The thyroid hormone receptor is a suppressor of ras-mediated transcription, proliferation, and transformationMutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways.Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.Bridging the Gap: A Regulator of NF-κB Linking Inflammation and Cancer.Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation.
P2860
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P2860
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@en
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@nl
type
label
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@en
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@nl
prefLabel
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@en
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@nl
P2093
P2860
P1476
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.
@en
P2093
J H Camonis
R G Pestell
S A Moskalenko
P2860
P304
P356
10.1128/MCB.20.21.8084-8092.2000
P407
P577
2000-11-01T00:00:00Z