about
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agentsFacile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adductDuplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.Structure and dynamics of ligand-template interactions of topoisomerase inhibitory analogs of Hoechst 33258: high field 1H-NMR and restrained molecular mechanics studies.Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule.Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole.(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprintingSpectrophotometric assay for enzyme-mediated unwinding of double-stranded DNA.Nearest neighbor effects on carcinogen binding to guanine runs in DNAA review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns.A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit.Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers.Sequence-specific cleavage of double-stranded DNA caused by X-ray ionization of the platinum atom in the Pt-bis-netropsin--DNA complex.Inducible alkylation of DNA by a quinone methide-peptide nucleic acid conjugate.Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.Sliding of alkylating anticancer drugs along the minor groove of DNA: new insights on sequence selectivityInduction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.Inhibition of initiation of simian virus 40 DNA replication in infected BSC-1 cells by the DNA alkylating drug adozelesin.Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
P2860
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P2860
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
Sequence selectivity of DNA covalent modification.
@en
Sequence selectivity of DNA covalent modification.
@nl
type
label
Sequence selectivity of DNA covalent modification.
@en
Sequence selectivity of DNA covalent modification.
@nl
prefLabel
Sequence selectivity of DNA covalent modification.
@en
Sequence selectivity of DNA covalent modification.
@nl
P356
P1476
Sequence selectivity of DNA covalent modification.
@en
P2093
Warpehoski MA
P304
P356
10.1021/TX00006A001
P577
1988-11-01T00:00:00Z