STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. - Wikidata - awgldk - TriplyDB

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

http://www.wikidata.org/entity/Q39540918

about

Targeting inflammation in pancreatic cancer: Clinical translation GEMMs as preclinical models for testing pancreatic cancer therapies Perspectives in the treatment of pancreatic adenocarcinoma Targeting the tumor microenvironment: JAK-STAT3 signaling Genetically engineered mouse models of pancreatic adenocarcinoma Exploiting inflammation for therapeutic gain in pancreatic cancer Regulation of Cellular Identity in Cancer JAK/STAT pathway dysregulation in tumors: a Drosophila perspective Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis STAT3 and its phosphorylation are involved in HIV-1 Tat-induced transactivation of glial fibrillary acidic protein Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia.MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.Alteration of EGFR spatiotemporal dynamics suppresses signal transduction.Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer.Risk factors for pancreatic cancer: underlying mechanisms and potential targets.Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine.Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells.Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation.The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.Targeting the interleukin-6/Jak/stat pathway in human malignancies Current knowledge on pancreatic cancer.Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.Role of IL-6 in the resolution of pancreatitis in obese mice CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice.The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

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P2860

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

http://www.wikidata.org/entity/Q39540918

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

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2011年论文

@zh

2011年论文

@zh-cn

name

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@en

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@nl

type

label

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@en

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@nl

prefLabel

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@en

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

@nl

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0008-5472.CAN-11-0908

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Cancer Research

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STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis

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Alexandros Tzatsos

http://www.w3.org/2001/XMLSchema#string

Claudius Conrad

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Cyril H Benes

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Jeffrey A Engelman

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Jeffrey Settleman

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Nabeel Bardeesy

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Ryan B Corcoran

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Vikram Deshpande

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P2860

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

Activation and association of Stat3 with Src in v-Src-transformed cell lines

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

Interleukin-6 family of cytokines and gp130

A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group

Requirement of serine phosphorylation for formation of STAT-promoter complexes

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

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5020-5029

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scholarly article

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14

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71

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Gianmarco Contino

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2011-05-17T00:00:00Z

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21586612

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3693754

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