Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. - Wikidata - awgldk - TriplyDB

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

http://www.wikidata.org/entity/Q39557681

about

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase Anti-apoptotic BCL-2 family proteins in acute neural injury A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia.Multiple functions of BCL-2 family proteins.A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer Mitochondrial death pathways in yeast and mammalian cells.Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma.Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death Molecular participants in mitochondrial cell death channel formation during neuronal ischemia.BAD: undertaker by night, candyman by day.Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.Central roles of apoptotic proteins in mitochondrial function.Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Long-term depression: a cell biological view Bcl-xL in neuroprotection and plasticity.Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways.Bcl-2 turns deadly.Physiological roles of the mitochondrial permeability transition pore.Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity.Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition.

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P2860

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

http://www.wikidata.org/entity/Q39557681

description

2007 nî lūn-bûn

@nan

2007年の論文

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2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@en

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@nl

type

label

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@en

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@nl

prefLabel

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@en

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@nl

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P1433

Journal of Neurophysiology

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Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

@en

P2093

Elizabeth A Jonas

http://www.w3.org/2001/XMLSchema#string

J Marie Hardwick

http://www.w3.org/2001/XMLSchema#string

John A Hickman

http://www.w3.org/2001/XMLSchema#string

Leonard K Kaczmarek

http://www.w3.org/2001/XMLSchema#string

P2860

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Inhibition of Bax channel-forming activity by Bcl-2

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform

The Bcl-2 apoptotic switch in cancer development and therapy

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

BCL-2 family members and the mitochondria in apoptosis

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1515-1522

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scholarly article

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10.1152/JN.00598.2007

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3

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99

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2007-12-26T00:00:00Z

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5689862

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18160428

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2836590

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