Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
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Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infectionGenes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile.Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient miceGranulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.The cysteine-cysteine family of chemokines RANTES, MIP-1alpha, and MIP-1beta induce trypanocidal activity in human macrophages via nitric oxide.Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.Biologic functions of the IFN-gamma receptors.In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the splePredominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene.Gamma interferon modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide-induced apoptosis during the acute phase of Trypanosoma cruzi infection: a possible role in immune response controlInterleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infectionDNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide.DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi geneInterferon-inducible effector mechanisms in cell-autonomous immunity.During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface proteinIFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain.The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi.The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi.Cell-specific activation of nuclear factor-kappaB by the parasite Trypanosoma cruzi promotes resistance to intracellular infection.Macrophage migration inhibitory factor contributes to host defense against acute Trypanosoma cruzi infection.Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice.Analysis of the dynamics of infiltrating CD4(+) T cell subsets in the heart during experimental Trypanosoma cruzi infectionInfluence of parasite load on renal function in mice acutely infected with Trypanosoma cruziNLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production.Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection.Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi InfectionTrypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells.IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.Differential Activation of Human Monocytes and Lymphocytes by Distinct Strains of Trypanosoma cruzi.Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection.IL18 Gene Variants Influence the Susceptibility to Chagas DiseaseMice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice.Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy.A magnetic resonance imaging study of intestinal dilation in Trypanosoma cruzi-infected mice deficient in nitric oxide synthaseDuring acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection.Chagas' disease: an update on immune mechanisms and therapeutic strategiesDo you see what I see: Recognition of protozoan parasites by Toll-like receptors.
P2860
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P2860
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Defective nitric oxide effecto ...... nducible nitric oxide synthase
@en
Defective nitric oxide effecto ...... ducible nitric oxide synthase.
@nl
type
label
Defective nitric oxide effecto ...... nducible nitric oxide synthase
@en
Defective nitric oxide effecto ...... ducible nitric oxide synthase.
@nl
prefLabel
Defective nitric oxide effecto ...... nducible nitric oxide synthase
@en
Defective nitric oxide effecto ...... ducible nitric oxide synthase.
@nl
P2093
P2860
P1476
Defective nitric oxide effecto ...... nducible nitric oxide synthase
@en
P2093
P2860
P304
P407
P577
1998-03-01T00:00:00Z