The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity.
about
Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: resistance maps to the UL6 gene.Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28Letermovir and inhibitors of the terminase complex: a promising new class of investigational antiviral drugs against human cytomegalovirusRole of human cytomegalovirus tegument proteins in virion assemblyStructure and inhibition of herpesvirus DNA packaging terminase nuclease domainPhosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirusA novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products.Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56A "coiled-coil" motif is important for oligomerization and DNA binding properties of human cytomegalovirus protein UL77The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid.Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging.Effects of mutations within the herpes simplex virus type 1 DNA encapsidation signal on packaging efficiency.Impact of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside and inhibitors of DNA, RNA, and protein synthesis on human cytomegalovirus genome maturation.Isolation and characterization of the herpes simplex virus 1 terminase complex.Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machineryHuman cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation.Point mutations in exon I of the herpes simplex virus putative terminase subunit, UL15, indicate that the most conserved residues are essential for cleavage and packaging.Intermolecular Complementation between Two Varicella-Zoster Virus pORF30 Terminase Domains Essential for DNA Encapsidation.The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89.Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides.Dramatic effects of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside on the genome structure, packaging, and egress of guinea pig cytomegalovirus.Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.The Varicella-zoster virus DNA encapsidation genes: Identification and characterization of the putative terminase subunits.Characterization of the Varicella-zoster virus ORF25 gene product: pORF25 interacts with multiple DNA encapsidation proteins.Human cytomegalovirus TRS1 protein is required for efficient assembly of DNA-containing capsids.Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle.DNA virus replication compartments.The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation.Herpesvirus Capsid Assembly and DNA Packaging.The terminase subunits pUL56 and pUL89 of human cytomegalovirus are DNA-metabolizing proteins with toroidal structureProteolytic processing of human cytomegalovirus glycoprotein B is dispensable for viral growth in culture.Identification of the ATP-binding site in the terminase subunit pUL56 of human cytomegalovirus.Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides.Mutational analysis of the herpes simplex virus type 1 DNA packaging protein UL33.The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome Encapsidation.The essential human cytomegalovirus gene UL52 is required for cleavage-packaging of the viral genome.
P2860
Q24515073-56D6AB5B-FD1D-47F0-B650-A094B62FCA63Q24675268-A053057B-E6CD-4760-AE2A-55D7DDC8AE64Q26783282-03F72EE1-F935-4CFD-9BA1-7E650C0C343CQ27015069-5C805201-2E35-446D-B690-856D1F56C762Q27664231-70C01875-A88F-4F4C-A11D-60C6DCCBC647Q28345180-2936D7C2-CE87-430E-8639-1DE1AA33A049Q28348812-87BDB1D6-B227-46E6-BEBC-D9A3F592B744Q28379493-EB5E1C41-10F6-48F7-AF87-FD7AFFF8904AQ28477354-D5AFEB40-D4D6-4A3E-963D-A40E64EE28DDQ30308062-E1D3C0F7-4674-4241-BADE-DFCB9BD2F531Q33783891-06DFAEE0-912E-48BF-9B3B-40747211D1BDQ33845102-EF215040-1BDE-49BB-8D23-889293F71324Q33930394-9D60AD4C-3868-40DD-B86E-D3A6B6A3703DQ34656890-078E305C-8E8E-44D4-A2BC-8D37CFA01221Q34699896-DE49CAA7-FCC5-47A2-B697-6DED03043F1EQ34922240-9A27377E-95A4-4059-9208-98A149A7CE0DQ35103227-E56CDB26-40BF-4B4D-AEAF-22D8B9D9D2BDQ35185894-DB1CFB66-6AC9-4FB7-BE33-34EF52A84E86Q35802925-4FFF71C4-AA33-4D96-9D17-9BD28C0448FDQ36080899-786E61F7-7F29-47AD-A74E-45C85E359D4BQ36559969-C0A4E3AE-7123-4D87-9F2B-840D79EE4720Q36944070-A2B578AE-9732-4178-96DD-E1B4523E6615Q36960023-63987463-ACF6-4105-862A-D5B7460FC1CAQ36987737-EFDEFF36-5F94-461A-A8B5-E8AFBE72F70DQ37158547-BE269A83-D2CD-4951-BF0B-6B8B06BF93B2Q37330959-0DB086C9-8113-4858-9E83-575A9FA68B12Q37511542-14997733-B7C4-4935-8D2A-658A2E713F4FQ37568962-7A243D58-FC3B-49A9-896A-E269F4CDD369Q37714026-ABF54428-BB93-4DD8-8668-31CAD1821CC6Q38164528-DAF3D3B2-1840-463B-9825-79BD6C767E79Q38631773-CB2C4EFC-41A2-4ACE-92CA-3C0923F2D3C7Q38709692-49984F26-5DAB-4AE8-9B26-6B314B0C800BQ39320351-3784FA49-6034-4DA9-89D3-BB608D60A1C0Q39538398-52A5A838-8C9E-4B44-AE20-E75044E10688Q39682047-E74B1229-381F-47EA-A31C-B4898D3C1B5DQ39733745-B7AEC220-B957-4EC4-A9B5-D3C939F7C3B3Q39797299-7B9653AB-3E40-4946-84D9-AD2B11E10D19Q39833688-054BB0FD-79C8-4E2D-AC87-EAEAD31946B5Q39892577-A2DCE628-2FD7-4F63-B215-F40BBA959003Q40035970-E8E1CB44-EB1D-47B7-8E79-15D35B807BCD
P2860
The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The gene product of human cyto ...... as specific nuclease activity.
@en
The gene product of human cyto ...... as specific nuclease activity.
@nl
type
label
The gene product of human cyto ...... as specific nuclease activity.
@en
The gene product of human cyto ...... as specific nuclease activity.
@nl
prefLabel
The gene product of human cyto ...... as specific nuclease activity.
@en
The gene product of human cyto ...... as specific nuclease activity.
@nl
P2860
P1433
P1476
The gene product of human cyto ...... has specific nuclease activity
@en
P2093
P2860
P304
P407
P50
P577
1998-03-01T00:00:00Z