Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. - Wikidata - awgldk - TriplyDB

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

http://www.wikidata.org/entity/Q39587350

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Modulating splicing with small molecular inhibitors of the spliceosome Alternative splicing for diseases, cancers, drugs, and databases Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells.SF3B1 and other novel cancer genes in chronic lymphocytic leukemia Alternative splicing and retinal degeneration HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia Radiosynthesis of antitumor spliceosome modulators.Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing.High antitumor activity of pladienolide B and its derivative in gastric cancer Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.Identification of small molecule inhibitors of pre-mRNA splicing.Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.Novel and emerging targeted-based cancer therapy agents and methods.Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages Targeting RNA splicing for disease therapy.Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells.Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43 Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome Test-firing ammunition for spliceosome inhibition in cancer.RNA splicing factors as oncoproteins and tumour suppressors.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms.Alternative splicing in cancer: implications for biology and therapy.Splicing factor mutations and cancer.Pre-mRNA splicing in cancer: the relevance in oncogenesis, treatment and drug resistance.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.Design and synthesis of analogues of natural products.

P2860

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P2860

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

http://www.wikidata.org/entity/Q39587350

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@en

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@nl

type

label

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@en

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@nl

prefLabel

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@en

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@nl

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Q39587350-C70A1070-2FCB-4548-9C6C-50C14306724E

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Q39587350-4D456E17-52E8-4EC7-8FF0-9ACBCA31C764

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Q39587350-4B40791F-A7B4-4DF7-BA17-3FDE8EFE9454

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Q39587350-EA495063-BADB-4E56-9F17-48FD2B0C95B9

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P932

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P356

P1433

ACS Chemical Biology

P1476

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.

@en

P2093

Carol C Edwards

http://www.w3.org/2001/XMLSchema#string

Chandraiah Lagisetti

http://www.w3.org/2001/XMLSchema#string

Liying Fan

http://www.w3.org/2001/XMLSchema#string

Thomas R Webb

http://www.w3.org/2001/XMLSchema#string

P2860

Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5

The pathobiology of splicing

Modulation of apoptosis by procaspase-2 short isoform: selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization.

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue

Substances that can change alternative splice-site selection.

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.

Antitumor compounds based on a natural product consensus pharmacophore.

Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

P304

582-589

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/CB100356K

http://www.w3.org/2001/XMLSchema#string

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

Philip M Potter

P577

2011-03-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49942358

http://www.w3.org/2001/XMLSchema#string

P698

21344922

http://www.w3.org/2001/XMLSchema#string

P932

3113647

http://www.w3.org/2001/XMLSchema#string