Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
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Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionHuman cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.The DNA damage response induced by infection with human cytomegalovirus and other virusesMurine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replicationInfection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome.Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureThe human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.Role of human cytomegalovirus immediate-early proteins in cell growth control.The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator.Herpesvirus lytic replication and the cell cycle: arresting new developmentsExon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.The coronavirus nucleocapsid is a multifunctional protein.Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activityThe Epstein-Barr virus immediate-early protein BZLF1 induces both a G(2) and a mitotic blockEvidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradationInhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle.Identification of herpesvirus proteins that contribute to G1/S arrest.SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replicationHost-viral effects of chromatin assembly factor 1 interaction with HCMV IE2Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding.Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.Deficiencies in Cellular Processes Modulated by the Retinoblastoma Protein Do Not Account for Reduced Human Cytomegalovirus Replication in Its AbsenceA short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replicationCell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cellsRegulation of the retinoblastoma proteins by the human herpesviruses.Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human CytomegalovirusHuman cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation stateKaposi's sarcoma-associated herpesvirus transactivator Rta induces cell cycle arrest in G0/G1 phase by stabilizing and promoting nuclear localization of p27kip.Murine coronavirus nonstructural protein p28 arrests cell cycle in G0/G1 phase.Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.H2B homology region of major immediate-early protein 1 is essential for murine cytomegalovirus to disrupt nuclear domain 10, but is not important for viral replication in cell culture.Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.Degradation of p21cip1 in cells productively infected with human cytomegalovirus.
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P2860
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G
@nl
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
@en
type
label
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G
@nl
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
@en
prefLabel
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G
@nl
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
@en
P2860
P1433
P1476
Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).
@en
P2093
C Hagemeier
L Wiebusch
P2860
P304
P407
P577
1999-11-01T00:00:00Z