The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. - Wikidata - awgldk - TriplyDB

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

http://www.wikidata.org/entity/Q33889383

about

Main roads to melanoma The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation EAPP, a novel E2F binding protein that modulates E2F-dependent transcription PML regulates p53 stability by sequestering Mdm2 to the nucleolus Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis Antiviral action of the tumor suppressor ARF CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53 Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21 p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2 Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis ZBP-89 promotes growth arrest through stabilization of p53 Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53 Regulation of p53 function and stability by phosphorylation N-terminal polyubiquitination and degradation of the Arf tumor suppressor Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)p53-independent functions of the p19(ARF) tumor suppressor Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway The combined status of ATM and p53 link tumor development with therapeutic response Epstein-Barr virus and Burkitt lymphoma Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2 Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells.Clinical Overview of MDM2/X-Targeted Therapies Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine Melanoma: from mutations to medicine A role for E2F activities in determining the fate of Myc-induced lymphomagenesis Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

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P2860

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

http://www.wikidata.org/entity/Q33889383

description

1998 nî lūn-bûn

@nan

1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

The alternative product from t ...... edback loop with p53 and MDM2.

@ast

The alternative product from t ...... edback loop with p53 and MDM2.

@en

type

label

The alternative product from t ...... edback loop with p53 and MDM2.

@ast

The alternative product from t ...... edback loop with p53 and MDM2.

@en

prefLabel

The alternative product from t ...... edback loop with p53 and MDM2.

@ast

The alternative product from t ...... edback loop with p53 and MDM2.

@en

P1433

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P2860

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P356

P1433

The EMBO Journal

P1476

The alternative product from t ...... edback loop with p53 and MDM2.

@en

P2093

B B McConnell

http://www.w3.org/2001/XMLSchema#string

E Hara

http://www.w3.org/2001/XMLSchema#string

F J Stott

http://www.w3.org/2001/XMLSchema#string

G Peters

http://www.w3.org/2001/XMLSchema#string

I Palmero

http://www.w3.org/2001/XMLSchema#string

K H Vousden

http://www.w3.org/2001/XMLSchema#string

K Ryan

http://www.w3.org/2001/XMLSchema#string

M C James

http://www.w3.org/2001/XMLSchema#string

M Starborg

http://www.w3.org/2001/XMLSchema#string

S Bates

http://www.w3.org/2001/XMLSchema#string

P2860

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

Growth suppression by p16ink4 requires functional retinoblastoma protein

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Mdm2 promotes the rapid degradation of p53

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

The retinoblastoma protein and cell cycle control

P304

5001-5014

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P31

scholarly article

P356

10.1093/EMBOJ/17.17.5001

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P407

P433

17

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P478

17

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P577

1998-09-01T00:00:00Z

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P5875

13560305

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P698

9724636

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P932

1170828

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