Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability.
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Mendelian disorders of the epigenetic machinery: tipping the balance of chromatin statesDiminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease MiceMolecular mechanism for age-related memory loss: the histone-binding protein RbAp48A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories.Globularity and language-readiness: generating new predictions by expanding the set of genes of interestGeneral Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.Prefrontal consolidation supports the attainment of fear memory accuracyp300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala.The role of nuclear PKMĪ¶ in memory maintenance.Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellumCBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors.Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.The role of histone acetylation in memory formation and cognitive impairments.Epigenetic memory: the Lamarckian brainCrebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formationCREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive agingEpigenetic mechanisms underlying learning and the inheritance of learned behaviorsHistone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury.Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.Is histone acetylation the most important physiological function for CBP and p300?Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorderAstrocyte Reactivity Following Blast Exposure Involves Aberrant Histone Acetylation.Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition.Acetyltransferases (HATs) as targets for neurological therapeuticsTranscriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity.Bromodomains as therapeutic targets.Epigenetic regulation of memory formation and maintenance.Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.The neuronal activity-driven transcriptome.Histone Acetylation Modifiers in the Pathogenesis of Alzheimer's Disease.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Ginsenoside Reduces Cognitive Impairment During Chronic Cerebral Hypoperfusion Through Brain-Derived Neurotrophic Factor Regulated by Epigenetic Modulation.CBP-Dependent memory consolidation in the prefrontal cortex supports object-location learning.Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning.Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction.The Mendelian disorders of the epigenetic machinery.Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
P2860
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P2860
Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability.
description
2011 nĆ® lÅ«n-bĆ»n
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2011幓ć®č«ę
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2011幓č«ę
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2011幓č«ę
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2011幓č«ę
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2011幓č«ę
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name
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@en
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@nl
type
label
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@en
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@nl
prefLabel
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@en
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@nl
P2093
P50
P1476
Ablation of CBP in forebrain p ...... oes not affect cell viability.
@en
P2093
Maria Jimenez-Minchan
Roman Olivares
P304
P356
10.1523/JNEUROSCI.4737-10.2011
P407
P577
2011-02-01T00:00:00Z