Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.
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Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasitesA high-throughput drug screen for Entamoeba histolytica identifies a new lead and targetInhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspectsTRP channels in schistosomesNew drug target in protozoan parasites: the role of thioredoxin reductaseThioredoxin glutathione reductase-dependent redox networks in platyhelminth parasitesThe redox biology of schistosome parasites and applications for drug developmentMapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray CrystallographyRecent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiomeThioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicumRepurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasisThioredoxin and glutathione systems differ in parasitic and free-living platyhelminthsCUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strainsMitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci).Insilico analysis of hypothetical proteins unveils putative metabolic pathways and essential genes in Leishmania donovani.Methaneseleninic acid is a substrate for truncated mammalian thioredoxin reductase: implications for the catalytic mechanism and redox signalingLinked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.Discovering Echinococcus granulosus thioredoxin glutathione reductase inhibitors through site-specific dynamic combinatorial chemistry.Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 PathwayInvestigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.Reflections on the biochemistry of Echinococcus: past, present and future.Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans.Targeting selenium metabolism and selenoproteins: novel avenues for drug discoveryThe biological activity of auranofin: implications for novel treatment of diseases.Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin.The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening.The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice.Differential expression of disulfide reductase enzymes in a free-living platyhelminth (Dugesia dorotocephala).Auranofin: repurposing an old drug for a golden new age.Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa.The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotypeIn vitro oxidative metabolism of xenobiotics in the lancet fluke (Dicrocoelium dendriticum) and the effects of albendazole and albendazole sulphoxide ex vivo.Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms.Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System.Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
P2860
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P2860
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@en
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@nl
type
label
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@en
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@nl
prefLabel
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@en
Platyhelminth mitochondrial an ...... t on selenium and glutathione.
@nl
P2093
P2860
P50
P356
P1476
Platyhelminth mitochondrial an ...... nt on selenium and glutathione
@en
P2093
Ana Denicola
Anton A Turanov
Darwin Izmendi
Gustavo Salinas
Vadim N Gladyshev
P2860
P304
17898-17907
P356
10.1074/JBC.M710609200
P407
P577
2008-04-11T00:00:00Z