In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
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Site-Specific PEGylation of Therapeutic ProteinsCys34-PEGylated Human Serum Albumin for Drug Binding and DeliveryGenetic PEGylationTunable degradation of maleimide-thiol adducts in reducing environmentsHomogeneous bispecifics by disulfide bridging.Bromomaleimide-linked bioconjugates are cleavable in mammalian cellsHomogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.Drug development: longer-lived proteins.Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery.Site-specific PEGylation of therapeutic proteins via optimization of both accessible reactive amino acid residues and PEG derivatives.Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.Polymer-based vehicles for therapeutic peptide delivery.Chemical Protein Modification through Cysteine.A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences.Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.Next-generation disulfide stapling: reduction and functional re-bridging all in one.Bromopyridazinedione-mediated protein and peptide bioconjugation.A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.Double quick, double click reversible peptide "stapling".Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide.Recent Advances in the Generation of Antibody-Nanomaterial Conjugates.Reversible surface functionalisation of emulsion-templated porous polymers using dithiophenol maleimide functional macromolecules.Dibromomaleimide as a facile, versatile linker for delivery applications.Dibromomaleimide Derivative as an Efficient Polymer Coupling Agent for Building Topological PolymersFluorescent and chemico-fluorescent responsive polymers from dithiomaleimide and dibromomaleimide functional monomersCross-conjugation of DNA, proteins and peptides via a pH switchBis-sulfide bioconjugates for glutathione triggered tumor responsive drug releaseAryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bondsMehrfache orthogonale Konjugationen mit Molekülgerüsten: Anwendung in der chemischen Biologie und Wirkstoff-Forschung
P2860
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P2860
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@en
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@nl
type
label
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@en
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@nl
prefLabel
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@en
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@nl
P2093
P2860
P356
P1476
In situ maleimide bridging of disulfides and a new approach to protein PEGylation.
@en
P2093
Andrew Tinker
Chris P Ryan
Felix F Schumacher
James R Baker
Mark E B Smith
Muriel Nobles
Stephen Caddick
P2860
P304
P356
10.1021/BC1004685
P577
2011-01-27T00:00:00Z