The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.
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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexAdenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblastsE4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex.RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesisAggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substratesThe respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.The chaperonin CCTα is required for efficient transcription and replication of rabies virus.CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein.PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.Adenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stressNuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins.Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells.
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The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@en
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@nl
type
label
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@en
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@nl
prefLabel
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@en
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@nl
P2093
P2860
P1433
P1476
The adenovirus type 5 E1B-55K ...... a CRM1-independent mechanism.
@en
P2093
P2860
P304
P356
10.1128/JVI.75.12.5677-5683.2001
P407
P577
2001-06-01T00:00:00Z