Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells.
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SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PMLAdenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcriptionAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsAdenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication.Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO ModificationAggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substratesIn vivo potential effects of adenovirus type 5 E1A and E1B on lung carcinogenesis and lymphoproliferative inflammation.The adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes.Human pathogens and the host cell SUMOylation system.Adenovirus degradation of cellular proteins.Sp100 isoform-specific regulation of human adenovirus 5 gene expression.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein.Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes.Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation.Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription.PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription.A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replicationAdenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stressE1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression.Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.
P2860
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P2860
Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
@zh-hant
name
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@en
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@nl
type
label
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@en
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@nl
prefLabel
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@en
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@nl
P2093
P2860
P356
P1433
P1476
Blockage of CRM1-dependent nuc ...... ormation of primary rat cells.
@en
P2093
Barbara Härtl
Christian Endter
Joachim Hauber
Thilo Spruss
Thomas Dobner
P2860
P2888
P356
10.1038/SJ.ONC.1208170
P407
P577
2005-01-01T00:00:00Z