Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.
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Epigenetic modulators as therapeutic targets in prostate cancerLargazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatinBiological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.Potent and orally efficacious bisthiazole-based histone deacetylase inhibitorsEvaluation of class I HDAC isoform selectivity of largazole analoguesSynthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsLargazole: from discovery to broad-spectrum therapy.Exploiting Acyl and Enol Azolium Intermediates via NHeterocyclic Carbene Catalyzed Reactions of Alpha-Reducible Aldehydes.Discovery and mechanism of natural products as modulators of histone acetylation.A continuum of progress: applications of N-hetereocyclic carbene catalysis in total synthesis.A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011.Muscarine, imidaozle, oxazole and thiazole alkaloids.Synthesis and biological evaluation of largazole zinc-binding group analogs.Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals.Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.Natural Agents-Mediated Targeting of Histone Deacetylases.Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation.
P2860
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P2860
Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Total syntheses of the histone ...... in complex molecule synthesis.
@en
Total syntheses of the histone ...... in complex molecule synthesis.
@nl
type
label
Total syntheses of the histone ...... in complex molecule synthesis.
@en
Total syntheses of the histone ...... in complex molecule synthesis.
@nl
prefLabel
Total syntheses of the histone ...... in complex molecule synthesis.
@en
Total syntheses of the histone ...... in complex molecule synthesis.
@nl
P2093
P2860
P356
P1476
Total syntheses of the histone ...... in complex molecule synthesis.
@en
P2093
Ching-Shih Chen
Craig J Forsyth
Po-Hsien Huang
P2860
P304
P356
10.1021/JO102478X
P407
P50
P577
2011-01-18T00:00:00Z